Here I give a brief overview of how the vaccine against #Monkeypox works. This vaccine is under various brand names including JYNNEOS (US), IMVANEX (EU), and IMVAMUNE (Canada) which is made by the company Bavarian Nordic. More info in 🧵
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This is a live, non-replicating vaccine which is derived from the Vaccinia virus, part of the Orthopox virus family. This family includes both smallpox and monkeypox, so pan immunity is achieved. This falls under the more ‘traditional’ types of vaccines. It is not mRNA tech.
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Remember that this is a two dose series, 4 weeks apart. Maximum immunity is achieved 2 weeks after your second dose. The vaccine has been approved for those pregnant or breast-feeding, 18 years or older.
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Replying to @sbstryker
I don’t like this since this is not how the studies / clinical trials were evaluated. Of course when these trials were run monkeypox was not widely circulating, therefore challenge studies (injecting pathogen) had to be completed in animal models.
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From this data all animals received 2 doses (1 month apart). Then they were challenged with mpox virus another month later. Across all studies, 80-100% of JYNNEOS-vaccinated animals survived compared to 0-40% survival of control animals who only received a saline solution.
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